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Image Search Results
Journal: Colloids and surfaces. B, Biointerfaces
Article Title: Peptide-targeted, stimuli-responsive polymersomes for delivering a cancer stemness inhibitor to cancer stem cell microtumors.
doi: 10.1016/j.colsurfb.2017.12.036
Figure Lengend Snippet: Fig. 5. Cellular uptake studies in monolayer and microtumor cultures of prostate and pancreatic cancer stem cells. Panels (A–F): prostate cancer stem cells (scale bar: 25 m), and
Article Snippet: Prostate cancer stem cells were maintained in human prostate cancer stem cell complete growth media with serum and antibiotics and pancreatic cancer stem cell were maintained in human
Techniques:
Journal: Colloids and surfaces. B, Biointerfaces
Article Title: Peptide-targeted, stimuli-responsive polymersomes for delivering a cancer stemness inhibitor to cancer stem cell microtumors.
doi: 10.1016/j.colsurfb.2017.12.036
Figure Lengend Snippet: Fig. 6. Expression of neuropilin-1 in prostate and pancreatic cancer stem cells as determined
Article Snippet: Prostate cancer stem cells were maintained in human prostate cancer stem cell complete growth media with serum and antibiotics and pancreatic cancer stem cell were maintained in human
Techniques: Expressing
Journal: Colloids and surfaces. B, Biointerfaces
Article Title: Peptide-targeted, stimuli-responsive polymersomes for delivering a cancer stemness inhibitor to cancer stem cell microtumors.
doi: 10.1016/j.colsurfb.2017.12.036
Figure Lengend Snippet: Fig. 7. The viability of prostate and pancreatic cancer stem cells in monolayer and spheroid cultures. (A) Monolayer cultures of prostate cancer stem cells, (B) monolayer cultures
Article Snippet: Prostate cancer stem cells were maintained in human prostate cancer stem cell complete growth media with serum and antibiotics and pancreatic cancer stem cell were maintained in human
Techniques:
Journal: Colloids and surfaces. B, Biointerfaces
Article Title: Peptide-targeted, stimuli-responsive polymersomes for delivering a cancer stemness inhibitor to cancer stem cell microtumors.
doi: 10.1016/j.colsurfb.2017.12.036
Figure Lengend Snippet: Fig. 9. Flow cytometry analysis of the effect of napabucasin on prostate (A) and pancreatic cancer stem cells (B) with Annexin V and PI staining.
Article Snippet: Prostate cancer stem cells were maintained in human prostate cancer stem cell complete growth media with serum and antibiotics and pancreatic cancer stem cell were maintained in human
Techniques: Flow Cytometry, Staining
Journal: Journal of materials chemistry. B
Article Title: Design and evaluation of nanoscale materials with programmed responsivity towards epigenetic enzymes.
doi: 10.1039/d4tb00514g
Figure Lengend Snippet: Fig. 6 Interaction of the block copolymers and HDAC8-responsive nanoparticles with different types of PDAC cells and non-cancerous HPNE cells in vitro. (A) PEG-block-poly(acetylated L-lysine) block copolymers studied in this work do not trigger cytotoxicity in different cell lines. (B) Chemical structure of the STAT3 inhibitor, Napabucasin (NAPA), which has been used as the model hydrophobic drug to demonstrate the encapsulation and HDAC-mediated release activity of the nanoparticles in the context of drug delivery. (C) HDAC 8 (1 mM) triggers the release of NAPA, and over 90% of the encapsulated drug is released from these nanoparticles after incubation with the enzyme for 3 h. The standard deviation of mean is taken for N = 3 replicates. Without the enzyme, the drug release rate and extent were significantly decreased. (D) NAPA-loaded nanoparticles showed a concentration- dependent effect on different types of cancer cells, with a more prominent effect on cancer stem cells (CSCs).
Article Snippet: The fourth cell variant is patient-derived
Techniques: Blocking Assay, In Vitro, Encapsulation, Activity Assay, Incubation, Standard Deviation, Concentration Assay